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Oliver Lenz Selected Research

Simeprevir

1/2018A 3-year follow-up study after treatment with simeprevir in combination with pegylated interferon-α and ribavirin for chronic hepatitis C virus infection.
1/2017Efficacy of a 12-Week Simeprevir Plus Peginterferon/Ribavirin (PR) Regimen in Treatment-Naïve Patients with Hepatitis C Virus (HCV) Genotype 4 (GT4) Infection and Mild-To-Moderate Fibrosis Displaying Early On-Treatment Virologic Response.
1/2017Efficacy, safety, and pharmacokinetics of simeprevir, daclatasvir, and ribavirin in patients with recurrent hepatitis C virus genotype 1b infection after orthotopic liver transplantation: The Phase II SATURN study.
1/2017Simeprevir with peginterferon α-2a/ribavirin for chronic hepatitis C virus genotype 1 infection in treatment-experienced patients: an open-label, rollover study.
5/2016Simeprevir plus peginterferon/ribavirin for HCV genotype 1-infected treatment-naïve patients in China and South Korea.
1/2016Simeprevir plus sofosbuvir (12 and 8 weeks) in hepatitis C virus genotype 1-infected patients without cirrhosis: OPTIMIST-1, a phase 3, randomized study.
1/2016Simeprevir plus sofosbuvir in patients with chronic hepatitis C virus genotype 1 infection and cirrhosis: A phase 3 study (OPTIMIST-2).
12/2015In Vitro Activity of Simeprevir against Hepatitis C Virus Genotype 1 Clinical Isolates and Its Correlation with NS3 Sequence and Site-Directed Mutants.
5/2015Virology analyses of HCV isolates from genotype 1-infected patients treated with simeprevir plus peginterferon/ribavirin in Phase IIb/III studies.
5/2015Efficacy and safety of simeprevir with PegIFN/ribavirin in naïve or experienced patients infected with chronic HCV genotype 4.
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Oliver Lenz Research Topics

Disease

26Infections
01/2023 - 03/2004
9Chronic Hepatitis B
08/2023 - 11/2020
8Fibrosis (Cirrhosis)
01/2020 - 01/2011
7Chronic Hepatitis C
01/2018 - 02/2014
6Chronic Kidney Failure (Chronic Renal Failure)
11/2014 - 03/2004
4Fatigue
01/2022 - 06/2014
4Pathologic Constriction (Stenosis)
11/2015 - 11/2006
4Hepatitis C
12/2013 - 11/2008
4Diabetic Nephropathies (Diabetic Nephropathy)
02/2009 - 02/2001
3Hepatitis B
01/2023 - 04/2019
3Headache (Headaches)
01/2022 - 08/2014
3Liver Diseases (Liver Disease)
05/2016 - 03/2014
3Lupus Nephritis
01/2013 - 03/2004
2Virus Diseases (Viral Diseases)
01/2023 - 01/2018
2Kidney Diseases (Kidney Disease)
11/2015 - 03/2015
2Nausea
12/2014 - 03/2004
2Exanthema (Rash)
08/2014 - 08/2014
2Neoplasms (Cancer)
03/2014 - 01/2012
2Chronic Renal Insufficiency
12/2013 - 11/2008
2Fistula
07/2009 - 09/2005
2Proteinuria
03/2009 - 11/2008
2Inflammation (Inflammations)
02/2009 - 02/2008
2Lassa Fever (Fever, Lassa)
12/2007 - 03/2004
1Chronic Hepatitis D
08/2023
1Dengue (Dengue Fever)
01/2023
1Renal Insufficiency (Renal Failure)
01/2023
1Acute Kidney Injury (Acute Renal Failure)
01/2023
1Disease Progression
11/2022
1Viremia
10/2022
1Hepatocellular Carcinoma (Hepatoma)
01/2021
1Persistent Infection
01/2020
1Aneurysm (Aneurysms)
11/2015
1Hematoma
11/2015
1Thrombosis (Thrombus)
03/2015
1Coinfection
12/2014
1Neutropenia
12/2014
1Blood-Borne Infections
03/2014
1Vascular Calcification
12/2013
1Hyperbilirubinemia
12/2013
1Adenocarcinoma
01/2012
1Pain (Aches)
06/2010
1Secondary Hyperparathyroidism
06/2010
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
03/2009
1Hypotension (Low Blood Pressure)
03/2009

Drug/Important Bio-Agent (IBA)

20SimeprevirIBA
01/2018 - 03/2010
15Ribavirin (Virazole)FDA LinkGeneric
01/2018 - 01/2011
10Protease Inhibitors (Protease Inhibitor)IBA
01/2016 - 06/2012
8JNJ-56136379IBA
01/2023 - 01/2020
7Antiviral Agents (Antivirals)IBA
01/2023 - 11/2008
7InterferonsIBA
01/2018 - 01/2011
6Hepatitis B e AntigensIBA
01/2023 - 04/2019
5RNA (Ribonucleic Acid)IBA
10/2022 - 12/2007
4Hepatitis B Surface Antigens (HBsAg)FDA Link
01/2023 - 01/2021
3Phosphates (Orthophosphate)IBA
12/2013 - 06/2010
2Biomarkers (Surrogate Marker)IBA
08/2023 - 11/2022
2AntigensIBA
01/2023 - 04/2019
2Small Interfering RNA (siRNA)IBA
01/2023 - 11/2022
2Alanine Transaminase (SGPT)IBA
01/2023 - 01/2022
2SofosbuvirIBA
01/2016 - 01/2016
2telaprevirIBA
01/2015 - 08/2014
2Interferon alpha-2 (Roferon-A)FDA Link
08/2014 - 08/2014
2Cyclophosphamide (Cytoxan)FDA LinkGeneric
01/2005 - 03/2004
2Mycophenolic Acid (Cellcept)FDA LinkGeneric
01/2005 - 03/2004
1Interferon-alpha (Interferon Alfa)IBA
08/2023
1DNA (Deoxyribonucleic Acid)IBA
01/2023
1Tenofovir (Viread)FDA Link
01/2023
1entecavirFDA Link
01/2023
1JNJ-1802IBA
01/2023
1NVR 3-778IBA
04/2019
1Blood Proteins (Serum Proteins)IBA
11/2018
1daclatasvirIBA
01/2017
1NucleotidesIBA
01/2016
1peginterferon alfa-2a (Pegasys)FDA Link
01/2015
1HCV NS3-4A Protease InhibitorsIBA
08/2014
1N- (3- amino- 1- (cyclobutylmethyl)- 2,3- dioxopropyl)- 3- (2- ((((1,1- dimethylethyl)amino)carbonyl)amino)- 3,3- dimethyl- 1- oxobutyl)- 6,6- dimethyl- 3- azabicyclo(3.1.0)hexan- 2- carboxamideIBA
08/2014
1Transaminases (Aminotransferases)IBA
12/2013
1Fibroblast Growth Factor-23IBA
11/2011
1Vitamin DFDA LinkGeneric
06/2010
1Parathyroid Hormone (Parathormone)IBA
06/2010
1Cinacalcet (Sensipar)FDA Link
06/2010
1CalciumIBA
06/2010
1lipoprotein cholesterolIBA
03/2009
1Tacrolimus (Prograf)FDA LinkGeneric
03/2009

Therapy/Procedure

10Therapeutics
08/2023 - 03/2004
7Renal Dialysis (Hemodialysis)
11/2015 - 09/2005
3Liver Transplantation
01/2021 - 03/2014
2Peritoneal Dialysis
11/2014 - 11/2011
2Catheters
07/2009 - 11/2006
1Investigational Therapies (Experimental Therapy)
08/2023
1Retreatment
08/2023
1Renal Replacement Therapy (Therapies, Renal Replacement)
01/2023
1Aftercare (After-Treatment)
01/2018
1Stents
11/2015
1Subcutaneous Injections
08/2014
1Drug Therapy (Chemotherapy)
01/2012
1Diet Therapy (Therapy, Diet)
06/2010
1Ligation
11/2009
1Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
11/2009
1Transplantation
03/2009
1Islets of Langerhans Transplantation
03/2009